Amide and williamson ether synthesis of acetophenetidin
Lab 6: phenacetin synthesis: 2 methods introduction: the purpose of this experiment was to synthesize phenacetin using two methods, the williamson ether synthesis using p-acetominophenol and bromoethane, and amide synthesis using acetic anhydride and p-phenetidine. Is acetophenetidin better synthesized by the amide route or williamson ether route i'm working on a organic chemistry lab i chose williamson ether synthesis because of the melting points i observed, but i don't have any further support. Purpose acetophenetidin can be formed through two methods, williamson ether synthesis and amide synthesis by working in groups of two we were able to complete both methods of synthesis routes the end result should be the synthesis of a similar product, by verification between the two individuals.
Synthesis of mdma essays: over 180,000 synthesis of mdma essays, synthesis of mdma term papers, synthesis of mdma research paper, book reports 184 990 essays, term and research papers available for unlimited access. Acetophenetidin was synthesized utilizing the williamson ether synthesis the product from this synthesis was compared to a product synthesized using another method, the amide synthesis method, in order to ascertain which method was most efficient for the synthesis of acetophenetidin. View notes - acetophenetidin+via+amide+route from chm 2211l at university of florida .
Acetophenetidin can be formed through two methods, williamson ether synthesis and amide synthesis by working in groups of two we were able to complete both methods of synthesis routes. The williamson ether synthesis is a reaction that converts alcohols (r-oh) into ethers (r-o-r) the first step in this reaction is forming the conjugate base of the alcohol (called an alcoxide) by reacting the alcohol with sodium metal. Amide synthesis includes the compounds p-phenetidine, acetic anhydride, naoac, hcl, and produces hoac williamson ether synthesis utilizes p-acetamidophenol, ch3na, ch3oh, ch3ch2, and bromoethane. Williamson ether synthesis of pentenol 3 with chloroacetamide 7 and coupling of acid 9b with n-methoxymethylamine led to the formation of amides 8 and 10b, respectively although the conversion was incomplete, bulky n , n -diisopropylamide 8 underwent cm with allyl halides promoted by catalyst iii to produce allyl halides 13c , d in 53% and 44% . The williamson ether synthesis the williamson ether synthesis is an organic reaction, forming an ether from an alkyl halide and an alcohol this reaction was.
Mechanism of amide synthesis of acetophenetidin mechanism of williamson ether synthesis of acetophenetidin how do these synthesis apply principles of green chemistry, and which one is greener. Spring 2004 adapted from pasto, johnson and miller, experiments and techniques in organic chemistry, prentice hall chemistry 3719l – week 7 williamson ether synthesis on an acetamidophenol. The procedure stated in chem 2120 experiment 6 williamson ether synthesis of phenacetin laboratory manual was followed without any major changes.
R das, d chakraborty, synthesis, 2011, 1621-1625 phosphomolybdic acid (pma) is a simple and efficient catalyst for the acetylation of structurally diverse alcohols, phenols, and amines acetylation reactions with acetic anhydride proceed in excellent yield in the presence of a catalytic amount of pma at ambient temperature within a . They are closed or plagiarism-shaped with two periods different to obtain movement when making testing from completing that the existence ultimately meets your sources and does, this also would that most part not be a document. The goals of this experiment are to determine if the products derived from amide synthesis and williamson ether synthesis are identical, and if one of the synthetic routes is more advantageous than the other - synthesis of acetophenetidin by amide synthesis introduction.
Amide and williamson ether synthesis of acetophenetidin
Williamson ether synthesis: phenacetin procedure: to a 5-ml conical vial equipped with a spin vane, weigh 100 mg of acetaminophen and 180 mg of powdered anhydrous potassium carbonate (k2co3). The procedure stated in chem 2120 experiment 6 williamson ether synthesis of phenacetin laboratory manual was followed without any major changes data and. Synthesis of acetophenetidin by amide synthesis the goals of this experiment are to determine if the products derived from amide synthesis and williamson ether synthesis are identical, and if one of the synthetic routes is more advantageous than the other.
Phenacetin may be synthesized as an example of the williamson ether synthesis: ethyl iodide, paracetamol, and anhydrous potassium carbonate are refluxed in 2-butanone to give the crude product, which is recrystallized from water. Between amide synthesis of acetophenetidin and williamson ether synthesis of acetophenetidin, is one procedure greener than the other explain your reasoning.
Study 58 chm 2211l midterm flashcards on williamson ether synthesis of acetophenetidin of the sodium acetate solution in amide synthesis of acetophenetidin. Was the amide or the williamson ether synthesis of acetophenetidin more green the amide synthesis because it used less water, less energy, and didn't require the need of the non-environmentally friendly compound bromoethane. Williamson ether synthesis mechanism and example synthesis of phenacetin ( common ochem lab reaction) for most ether syntheses strong bases such as amide ion are necessary to show the formal step-by-step electron-pushing mechanism for the reaction in this experiment. Synthesis of acetophenetidin by williamson ether synthesis produced purer crystals, but amide synthesis produced a larger crude mass (greener pathway) recrystallizing the crude product formed from amide synthesis gave purer crystals that were identical to those formed by williamson ether synthesis.